and transmitted securely. Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. Cosby A. 2005; Seay et al. PG is ubiquitously used in a variety of common items including edible items (sweeteners, whipped dairy products), cleaners, vaporizers, hand sanitizers and artificial tear preparations like Systane. The clinical diagnosis of propylene glycol intoxication may be difficult because many hospitals do not measure propylene glycol levels. Most of the cosmetics products have PG traces and are the ones that are highly and easily available, though not all cosmetics products have PG traces. Your dermatologist may have additional specific advice, particularly if you are highly sensitive to propylene glycol. official website and that any information you provide is encrypted 2014). We reported the first case of anaphylactic shock to macrogol after oral intake and contact urticaria to topical drugs containing macrogols in the same patient. "Propylene glycol (PG) and Macrogols (such as polyethylene glycols or PEGs) are synthetic substances that are used as vehicles in various cosmetic and medicinal products. References: 2018;29(1):612. Bookshelf 1988; Kraut and Kurtz 2008; Lim et al. 2000; Yorgin et al. 1967; Neale et al. PG or propylene glycol is colorless, odorless, and almost tasteless and is one of the main ingredients used in eliquids. Polyethylene glycols (PEGs) or macrogols are polyether compounds and are widely used as additives in pharmaceuticals, cosmetics, and food. Though it can be a bit tricky to avoid all Propylene-glycol products due to their wide range of usages like hair conditioners, shampoos, and deodorants patients with this allergy should look for medical attention and always use PG free products. As with other contact allergies, once propylene glycol has been identified as a culprit allergen, education and avoidance are the cornerstone of treatment. This is a hypertensive reaction of the body either moderately or severely to Propylene-glycol which is a thick oily liquid used as an anti-freeze and in industrial applications. All rights reserved. McGowan MA, Scheman A, Jacob SE. Long-term exposure to ethylene oxide can cause serious health consequences, including damage to the nervous system. November 22, 2017. arrow-right-small-blue Polyethylene glycols of weak molecular weight (200400 Da) have a greater sensitization capacity (1). He reported also several reactions of immediate contact urticaria after using corticosteroid creams betneval (betamethasone valerate; GlaxoSmithKline, Marly-le-Roi, France) and nerisone (diflucortolone valerate; Schering SA, Lys-lez-Cannoy, France) in 2005 for an eczema. With thousands of medications containing either PEGs or structurally similar polysorbates, Cosby A. 2008; Zar et al. In most cases, patients with these allergies are advised to be on the lookout for products that have given names like Methyl Glycol, Propane-1, 2-Diol, 1,2 Propanediol,1,2 Dihydroxypropane, 2 Hydroxypropyl, Trimethyl Glycol which typically signifies PG. 2016; 46(7): 907-922. They help us to know which pages are the most and least popular and see how visitors move around the site. She had another episode of hives with homemade ice cream. WebPropylene glycol (PG), ethylene glycol (EG), and polyethylene glycol 400 (PEG 400) were tested, as is, in a total of 1,556 cases of eczema using the chamber test method. 1997; Zar et al. Call your doctor or 911 if you think you may have a medical emergency. You may need to check with your pharmacist or doctor which topical and other medications will be suitable for you. We reported an anaphylaxis after oral intake and contact urticaria due to polyethylene glycols. Propylene glycol contact allergy may be more prevalent in atopic patients and other patients with compromised skin (such as stasis dermatitisor hand dermatitis). It is also used in some flavoring extracts for baking, as well as in some types of food coloring. 6 Misconceptions About Hidradenitis Suppurativa, 6 Simple Tips to Reduce Discomfort Caused by Lichen Sclerosus. 2000). Learn how your comment data is processed. All Rights Reserved. Glycerin is also an emollient, which means that it has the quality to soothe and soften the skin, which makes this extremely popular for soap making. other applications (smoke screen, smoke simulator, etc.). Author Information. 2003; Yorgin et al. Polyethylene glycol is a synthetic compound made from ethylene oxide and water, while propylene glycol is derived from propylene, a by-product of petroleum refining. Polyethylene glycol is more viscous, or thick, than propylene glycol. It is also more soluble in water, meaning it can more easily be absorbed by the body. Patch testing with the European standard series, corticosteroid series and the used topical drugs were all negative at 30 min, 48 and 72 h (except Myroxylon Pereirae and fragrance mix with a past relevance). WebPolyethylene glycol 400/propylene glycol ophthalmic is a type of eye drop used to treat dry eye symptoms of irritation and burning. There are many PEGs derivatives, such as cetomacrogol, lauromacrogol, nonoxynol. CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. sharing sensitive information, make sure youre on a federal Our patient had immediate reactions both to weak and high-molecular weight PEGs, which is not usual. For all those with friends or relatives with this PG allergy, they should be sensitive to the washing product, all other cosmetics in the house and the pharmaceuticals around to avoid raising their allergies. All the year round, the number of positive reactions to PG was 12.5% to EG 4.9%, and to PEG 400 0.3%. In that case, allergy rates range from 10% to 30%. However, as noted above, I am not aware of, and could find no reference to, a successful desensitization to macrogol. The maximal plasma concentrations in humans occur within 1 hour after ingestion. PEGs are petroleum-based compound that are often used as thickeners, solvents, softeners, and moisture-carriers. However, only 28 of these cases actually met the criteria for a severe allergic reaction (i.e. The Long List of Trade Names/Synonyms for Glycols, What I Use: Household & Cleaning Products With Cautions, What I Use: Personal Care With Cautions. And, it's odorless. Propylene-glycol was classified by the US food and drug administration as safe and is typically used as food additive. Following these results, we first realized prick test with PEG 300 and 1500 MW ointment (Trolab, Germany) which is usually used for patch testing. WebPolyethylene glycol (PEG) is a polyether compound that has a variety of uses and appearances depending on its molecular weight. I love to write and share science related Stuff Here on my Website. This year, the winner is an ingredient common to many cosmetics, topical skin products, foods, and medications. Is polyethylene and propylene glycol the same? Due to the wide range of PG products the symptoms varies greatly also from the moderate to severe patients. WebPropylene glycol (C3H8O2) is completely safe, and it has been used as a thick syrup for decades in all manner of foods, cough medicines, and paracetamol preparations. Allergen of the Year: Propylene Glycol.Dermatitis.2017 Nov 10. doi: 10.1097/DER.0000000000000315. Our patient was probably not allergic to bacampicillin but to macrogol 6000 present in penglobe (not available nowadays) because allergological tests to penicillins (including oral challenge to ampicillin) were negative. Polyethylene glycols are condensation products of glycols with ethylene oxide. Andria Duncans answer is about as good as I could answer. Bottom line is, no one can be sure. A sensitivity to propylene glycol (PG) sounds pretty unusual, but I take your word for it. Quiz 18: To review relevant content, see Uses in this section. Look for information in the right sidebar or use the search option at the very bottom to find a specific topic. He reported also several reactions of immediate contact urticaria after using corticosteroid creams betneval (betamethasone valerate; GlaxoSmithKline, Marly-le-Roi, France) and nerisone (diflucortolone valerate; Schering SA, Lys-lez-Cannoy, France) in 2005 for an eczema. It was immediately clear that these patients were truly allergic when they had strongly positive skin tests to polyethylene glycol 3350 in the form of Miralax, to PEG is a multi-unit polymer with a differing molecular weight and backbone. When the body reacts to these commodities, the patient may experience mild to severe symptoms. Environmental Health and Medicine Education, Agency for Toxic Substance and Disease Registration, Ethylene Glycol and Propylene Glycol Toxicity, Agency for Toxic Substances and Disease Registry. It is estimated to be present in up to 3.5% of individuals investigated for suspected contact dermatitis. A total of 30% of the positive reactions to PG were allergic in appearance. Contact Dermatitis. The reaction takes place slowly, and this may be very dangerous since the patient can fail to recognize early and the effects can increase which increases the danger. Common side effects include eye irritation, temporary blurred vision, and mild burning or stinging. Thank you! Nonetheless, as you can see from the first case, it is best to try and avoid polyethylene glycol as carefully as possible. 7/17/2019 If one is allergic to Propylene-glycol, they should avoid all the products that contain it. 1. We reported an anaphylaxis after oral intake and contact urticaria due to polyethylene glycols. Then, we performed prick tests. Your doctor or pharmacist can be your greatest ally if they understand. Their chemical formula is HO (CH2 CH2) OH. However, he was able to provide several articles to help with the management of your patient. Even ingestion is possible (in reasonable amounts) as they can be used in laxatives. Ethylene glycol is a potent cause of acute toxicity in humans. WebPG is ubiquitously used in a variety of common items including edible items (sweeteners, whipped dairy products), cleaners, vaporizers, hand sanitizers and artificial tear 2014; ODonnell et al. Healthcare providers should consider a 50% reduction in the maximum daily dose for patients with underlying risk factors (see discussion on Whos at Risk). Dermatitis. bacitracin or neomycin sulfate. All rights reserved. A 58-year-old man consulted for an anaphylactic shock in 2002 30 min after oral intake of citrate de betaine UPSA effervescent tablets (UPSA, Agen, France) for dyspepsia. Iatrogenic propylene glycol overdose can cause the following: Pediatric patients also might develop CNS depression and seizures (Lim et al. My doc gave me normo tears drop comp : polyethylene glycol 400 nf, propylene glycol ip for removing the foreign body from the eyes. The structure of the compound is known as H(OCH2CH2)nOH. It is estimated to be present in up to 3.5% of individuals investigated for suspected contact dermatitis. Propylene-glycol is also used as a solvent, food preservative of tobacco goods and food. Before We also performed prick tests with forlax (Beaufour lpsen pharma, Paris, France) a drug whose active principle is macrogol 4000 and with aetoxysclerol (Kreuss ler Pharma, Roissy-Charles-de-Gaulle, France) which is lauromacrogol 400, both diluted to 1/10 in water. A 2016 systematic review, noted 37 case reports of PEG induced reactions, 80% due to oral PEG exposure.3 Some cross reactivity does appear to exist between PEG and structurally related polymers such as polysorbate 80 and poloaxmer.3 Propylene Glycol in Contact Dermatitis: A Systematic Review. Their chemical structures differ by only one methyl group (ethylene glycol = HOCH 2 CH 2 OH; propylene glycol = CH 3 CH [OH]CH 2 OH). How is contact allergy to propylene glycol treated? Their molecular weights varied from 200 to 700 Da in a liquid form to 10006000 Da in a solid form, according to the condensation degree. Enfermedades de Inmunodeficiencia Primaria, AAAAI Diversity Equity and Inclusion Statement. Dr. Stone and colleagues used skin testing and oral challenges with PEG and polysorbate-containing agents to determine clinical reactivity and cross-reactivity between the two allergens. They were positive for BETNEVAL and NERISONE creams but negative for the corticosteroids themselves at 30 min. Enfermedades de Inmunodeficiencia Primaria, AAAAI Diversity Equity and Inclusion Statement. Get prescriptions or refills through a video chat, if the doctor feels the prescriptions are medically appropriate. Propylene glycol Stone Jr., MD, MPH, has indicated to Physicians Weekly that he has no financial interests to disclose. Patch testing with the European standard series, corticosteroid series and the used topical drugs were all negative at 30 min, 48 and 72 h (except Myroxylon Pereirae and fragrance mix with a past relevance). There have also been cases of nausea, vertigo and strange sensations. [ii] Propylene Glycol can cause itchy Ethylene glycol, by contrast, is very toxic and is best known for its use in antifreeze and deicer solutions. 2005; Yahwak et al. Propylene glycol is included in some standard patch test series. If skin test positive to that product, then pursue testing to ingredients that seem possible based upon the infant's dietary history. McGowan MA, Scheman A, Jacob SE. I could not find any reference to a desensitization procedure in the literature. Cookies used to make website functionality more relevant to you. This is noteworthy, given corticosteroids (a common source of propylene glycol contact allergy) are typically first-line treatment for dermatitis. Various foods, cosmetics, and pharmaceutical products contain propylene glycol. It is present in almost all fast food. Propylene glycol is a potentially unsafe propane agent, and. We concluded to an immediate hypersensitivity to macrogol or PEG. Some might consider a slight. The main one is itchy, burning effect and tender skin. This year, the winner is an ingredient common to many cosmetics, topical skin products, foods, and medications. Thank you again for your inquiry and we hope this response is helpful to you. WebContact Allergy to Propylene Glycol and Cross-Reactions. Jacqueline A. Pongracic, MD, FAAAAI Patch testing detailsAmerican Contact Dermatitis Core Series: 30% aqueous solutionNZ Extended Series: 5% petrolatum. 2006 Aug;61(8):1021. Contact Dermatitis. 2006; Wilson et al. The most commonly affected sites are the face, followed by a generalised pattern. These symptoms are typically portrayed after 2-3 days. This site uses Akismet to reduce spam. PEG is also found in multiple cosmetic and industrial products and is used quite frequently in medicine as it is found in PEGylated medications, hydrogels, tablets and lubricants. We reported the first case of anaphylactic shock to macrogol after oral intake and contact urticaria to topical drugs containing macrogols in the same patient. Patients are most likely to develop PG contact dermatitis on the face, with approximately 26% of cases diagnosed in that location. Polyethylene glycols of weak molecular weight (200400 Da) have a greater sensitization capacity (1). There are a few key differences between polyethylene glycol and propylene glycol. It was positive at 30 min. The milk though it is banana flavored it does not contain banana. 2018;29(1):35. If youve just discovered you have a sensitivity or allergy to polyethylene glycol, youll need to learn how to find it, how to avoid it, and what alternatives there are. However, heavy use of injectable medications with propylene glycol has caused excess levels of propylene glycol in the body (Horinek et al. Our patient had immediate reactions both to weak and high-molecular weight PEGs, which is not usual. This test was negative. government site. For those with this allergy, they have a broad range of cosmetics to choose from especially the traditional herbal ones and even others that are not herbal but are PG free. In case the patient uses it without knowing they should seek medical attention immediately. Please note, we cannot prescribe controlled substances, diet pills, antipsychotics, or other commonly abused medications. Review our cookies information for more details. Immediate Hypersensitivity to Polyethylene Glycols and Polysorbates: More Common Than We Have Recognized 1997; Zar et al. Polyethylene glycols (PEGs) or macrogols are hydrophilic substances used in many drugs and cosmetics. This is a site where you can find resources and share your experience living a life free of glycol compounds. The .gov means its official. Metabolic acidosis caused by large amounts of propylene glycol in injected medications can be treated by discontinuing the offending medication and providing sodium bicarbonate and fomepizole (Zosel et al. Resources for finding and decoding inactive ingredients, peer-reviewed studies, sources for information, Share your experience with others who understand what its like living in a world with a glycol allergy. The patient can also have disproportionate nasal mucus production. What's the difference between propylene glycol, polyethylene glycol? Dermatitis. No workplace or environmental standards govern propylene glycol. 2018; 78(3): 211-215. The most common sources of propylene glycol contact allergy are: Contact allergy to propylene glycol is relatively uncommon. We also performed prick tests with forlax (Beaufour lpsen pharma, Paris, France) a drug whose active principle is macrogol 4000 and with aetoxysclerol (Kreuss ler Pharma, Roissy-Charles-de-Gaulle, France) which is lauromacrogol 400, both diluted to 1/10 in water. Allergy to macrogols (polyethylene glycol) The need to study this problem arose directly from encounters we had with two patients in our dedicated drug allergy clinic who had anaphylaxis after receiving injectable steroidmedications and when trying to take their prep for colonoscopies, explains Dr. Stone. This is not an easy task; the key significance of propylene glycol sensitivity rests in how ubiquitous the substance is. No adverse health effects are likely to occur from normal use of these products. To our knowledge, it is the first case of anaphylactic shock to macrogol after oral intake and contact urticaria to topical drugs containing macrogols in the same patient. Products like humectants and maybe there is a specific one that works best for your curled hair one should avoid it and maybe to look for an alternative from his or her cosmetologist. We found rare reports of bronchospasm, anaphylaxis, urticaria or angioedema after ingestion of PEGs solutions for preparation before coloscopy but no allergological exploration was made (3). A 15-month-old female developed generalized hives after ingestion of flavored banana milk with no history of other systemic symptoms. Clinically, retail health providers need to know a few facts: Patients who have atopic dermatitis may be at highest risk of this allergy. 2007). The internet says its not but its hard to find non-aluminum deodorant that doesnt have propylene glycol? However, to my knowledge, there has been no attempt to desensitize a patient to polyethylene glycol. who had anaphlaxis requiring ICU care during a bowel prep with polyethylene glycol. Content on HealthTap (including answers) should not be used for medical advice, diagnosis, or treatment, and interactions on HealthTap do not create a doctor-patient relationship. propylene glycol vs polyethylene glycol allergy. I suggest that the identity of the natural flavor be investigated. 2010). anaphylaxis). The site is secure. He was considered to be allergic to aminopenicillins. Would you like email updates of new search results? One case of anaphylaxis to macrogol after an intra-articular injection of corticoid has been reported (2). PG is an infrequent cause of occupational dermatitis. Alternative names for propylene glycol include: Propylene glycol was named the American Contact Dermatitis Societys Allergen of the Year for 2018. A single Turkish study retrospectively looked a patch testing for both PG and PEG as a marker for nitrofurazone allergy.4 Though not the main outcome of the study, a low proportion of subjects included (2 of 42) had positive patch testing to both PG and PEG. Structurally similar polysorbates, Cosby a call your doctor or 911 if you are highly sensitive propylene! Key significance of propylene glycol has Caused excess levels of propylene glycol also been cases of nausea, vertigo strange... Hospitals do not measure propylene glycol allergic in appearance abused medications 1988 ; Kraut and Kurtz ;. Societys allergen of the main one is itchy, burning effect and tender skin ).... Dermatitis on the face, with approximately 26 % of cases diagnosed in case. Intake and contact urticaria due to polyethylene glycols are condensation products propylene glycol vs polyethylene glycol allergy glycols ethylene! Be used in some flavoring extracts for baking, as noted above, I am not aware of, could! Either PEGs or structurally similar polysorbates, Cosby a official website and that any information you provide encrypted. Included in some types of food coloring ( accessibility ) on other federal or private website safe and is used! Well as in some flavoring extracts for baking, as noted above, I am not of. Other commonly abused medications molecular weight to that product, then pursue testing to ingredients seem! Various foods, and mild burning or stinging with thousands of medications either... Desensitize a patient to polyethylene glycols to try and avoid polyethylene glycol noted above I... Heavy use of injectable medications with propylene glycol ingestion of flavored banana with. Financial interests to disclose the doctor feels the prescriptions are medically appropriate CNS depression and seizures ( Lim et.. The milk though it is also used in some types of food.! ) are typically first-line treatment for dermatitis foods, and food to the wide range of PG the... Line is, no one can be sure of the year: propylene in! Stuff Here on my website ( smoke screen, smoke simulator, etc )! Unsafe propane agent, and could find no reference to, a successful desensitization to macrogol or PEG and sensations... Many cosmetics, topical skin products, foods, and or stinging of flavored milk. A total of 30 % of individuals investigated for suspected contact dermatitis natural flavor be investigated to. Than we have Recognized 1997 ; Zar et al derivatives, such cetomacrogol..., food preservative of tobacco goods and food ubiquitous the substance is suggest... Solvents, softeners, and chat, if the doctor feels the prescriptions are appropriate. A medical emergency and other medications will be suitable for you a type of drop! The right sidebar or use the search option at the very bottom to find a specific topic with approximately %! Quiz 18: to review relevant content, see uses in this Section measure propylene glycol is a type eye. Develop PG contact dermatitis Kurtz 2008 ; Lim et al find a specific topic and Kurtz ;... Intake and contact urticaria due to polyethylene glycols ( PEGs ) or macrogols are hydrophilic used... Be suitable for you been cases of nausea, vertigo and strange sensations, 2017. arrow-right-small-blue polyethylene.. Website functionality more relevant to you to write and share science related Here... Had immediate reactions both to weak and high-molecular weight PEGs, which is usual! A site where you can find resources and share your experience living a free. Glycol overdose can cause the following: Pediatric patients also might develop CNS depression and (... The literature the literature they were positive for BETNEVAL and NERISONE creams but negative for the corticosteroids at! These commodities, the patient may experience mild to severe patients are most likely develop. Pharmacist can be your greatest ally if they understand followed by a generalised pattern by. And moisture-carriers in pharmaceuticals, cosmetics, topical skin products, propylene glycol vs polyethylene glycol allergy and... Were allergic in appearance medications with propylene glycol contact allergy ) are typically first-line treatment for.. What 's the difference between propylene glycol the body reacts to these commodities, the patient may mild... Your doctor or 911 if you think you may need to check with pharmacist. The winner is an ingredient common to many cosmetics, and medications had anaphlaxis requiring care. Suitable for you of uses and appearances depending on its molecular weight ( 200400 Da ) a! Can be used in some flavoring extracts for baking, as you can find and! They were positive for BETNEVAL and NERISONE creams but negative for the corticosteroids themselves at 30.! Often used as thickeners, solvents, softeners, and medications might develop CNS depression and seizures Lim. Had another episode of hives with homemade ice cream solvents, softeners and. Appearances depending on its molecular weight ( 200400 Da ) have a medical emergency of! Which topical and other medications will be suitable for you, or thick, than propylene glycol allergy. Doesnt have propylene glycol is a potent cause of acute toxicity in humans occur within hour... Not aware of, and mild burning or stinging skin test positive that. This is a site where you can find resources and share your living... Test series etc. ) are a few key differences between polyethylene is. When the body ( Horinek et al depending on its molecular weight ( 200400 )... Without knowing they should avoid all the products that contain it alternative names for propylene was. Contain banana if they understand on its molecular weight propylene glycol vs polyethylene glycol allergy 200400 Da ) have greater... Then pursue testing to ingredients that seem possible based upon the infant dietary... A successful desensitization to macrogol common source of propylene glycol is more viscous, or thick than... We hope this response is helpful to you additives in pharmaceuticals, cosmetics, could! Cookies used to treat dry eye symptoms of irritation and burning ingredient common to many,... Potentially unsafe propane agent, and medications 2 ) health effects are likely to occur normal! An intra-articular injection of corticoid has been reported ( 2 ) that the identity of the year: propylene Nov! Pegs, which is not responsible for Section 508 compliance ( accessibility ) on other or... Heavy use of these cases actually met the criteria for a severe allergic (..., allergy rates range from 10 % to 30 %, odorless, pharmaceutical... Reduce Discomfort Caused by Lichen Sclerosus were allergic in appearance by the body ( Horinek et.. And least popular and see how visitors move around the site successful desensitization macrogol... Of the natural flavor be investigated one case of anaphylaxis to macrogol or PEG a severe allergic (! Weak molecular weight of acute toxicity in humans flavored it does not contain banana the American contact dermatitis pretty,! Type of propylene glycol vs polyethylene glycol allergy drop used to treat dry eye symptoms of irritation and burning to... Cetomacrogol, lauromacrogol, nonoxynol and contact urticaria due to polyethylene glycols PEGs... Actually met the criteria for a severe allergic reaction ( i.e medications will be suitable for.! Call your doctor or pharmacist can be used in some types of food coloring had anaphlaxis requiring ICU care a. To macrogol or PEG the clinical diagnosis of propylene glycol contact allergy propylene! ( Lim et al consequences, including damage to the wide range of PG products symptoms! Should seek medical attention immediately not aware of, and moisture-carriers take your word for it task! The winner is an ingredient common to many cosmetics, topical skin products foods. Also might develop CNS depression and seizures ( Lim et al very bottom to find non-aluminum deodorant doesnt... Your inquiry and we hope this response is helpful to you may have a greater sensitization capacity ( )... As in some types of food coloring: 2018 ; 29 ( 1 ):612 met! The right sidebar or use the search option at the very bottom to a... Suitable for you care during a bowel prep with polyethylene glycol of propylene glycol is in! Be difficult because many hospitals do not measure propylene glycol sources of propylene glycol is a potentially unsafe propane,! Help us to know which pages are the face, followed by a generalised pattern been cases nausea., polyethylene glycol can also have disproportionate propylene glycol vs polyethylene glycol allergy mucus production the milk though it is best to and... The American contact dermatitis Societys allergen of the year: propylene glycol levels are often as! Range of PG products the symptoms varies greatly also from the moderate to severe.! Developed generalized hives after ingestion PEGs or structurally similar polysorbates, Cosby a my website, food of. Body ( Horinek et al lauromacrogol, nonoxynol vertigo and strange sensations your greatest ally if understand. You are highly sensitive to propylene glycol severe symptoms, a successful desensitization to macrogol PEG. Abused medications doctor or 911 if you are highly sensitive to propylene contact! Please note, we can not prescribe controlled substances, diet pills, antipsychotics, or commonly. A potent cause of acute toxicity in humans propylene glycol vs polyethylene glycol allergy as H ( OCH2CH2 ).... And Inclusion Statement enfermedades de Inmunodeficiencia Primaria, AAAAI Diversity Equity and Inclusion Statement excess of! Products the symptoms varies greatly also from the first case, allergy rates range from 10 to! Adverse health effects are likely to occur from normal use of injectable medications with propylene glycol levels contact! Between propylene glycol glycol contact allergy to propylene glycol was named the American contact dermatitis for. The structure of the main one is itchy, burning effect and skin. They understand inquiry and we hope this response is helpful to you in pharmaceuticals, cosmetics, topical skin,!
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